Alzheimer’s Disease

Project Overview

Andreas’ research has shown that sequence mutations associated with Alzheimer’s Disease are more likely to be found in regions of the genome that are active in the immune cells of the blood, and not within the brain. The Neurogenomics Laboratory aims to uncover what influence those mutations have on the disease process by combining a computational, big data approach with new experimental technologies to manipulate the genome.

Gjoneska E*, Pfenning AR*, Kundaje A, Tsai L-H, Kellis M. Conserved epigenomic signals in mice and human reveal immune basis of Alzheimer’s disease. (2015) Nature. PMID: 25693568

Kundaje A, Meuleman W, Ernst J, et al. (Author #21/93, equal contribution with first author in integrative analysis) Integrative analysis of 111 reference human epigenomes. (2015) Nature. PMID: 25693563